Bone Marrow Transplant for Pediatric Non-Hodgkin Lymphoma (DLBCL, FL, MCL)

• Puntura del midollo osseo con analisi citogenetica
• Consulto con un ematologo
• Diagnosi completa dei linfomi
• Esame del sangue per linfoma
• Biopsia del linfonodo sentinella
• Consulto con un oncoematologo
• Trapianto autologo di midollo osseo
• Trapianto di midollo osseo allogenico da donatore non correlato
• Trapianto di midollo osseo allogenico da donatore consanguineo
• Trapianto di midollo osseo
• Test anti-HIV
• Test Anti-HBC
• Test Anti-HCVAb
• Esami del sangue
• Esame di biochimica del sangue
• Biopsia
• Radiografia del torace
• Emocromo completo (CBC)
• Consultazione con un immunologo
• Consultazione con un cardiologo
• Consultazione con un ematologo pediatrico
• Consultazione con un pediatra
• Emocromo completo con marcatori tumorali e proteinogramma
• Elettrocardiogramma (ECG)
• Ecocardiografia
• Risonanza magnetica della testa
• PET/TC
• Consultazione con un oncoematologo
• Servizi infermieristici 24 ore su 24
• 3 pasti al giorno dal nutrizionista

• 30 giorni in ospedale

• Trasferimento aeroporto-clinica-aeroporto

Bone Marrow Transplant for Pediatric Non-Hodgkin Lymphoma

(DLBCL, FL, MCL)
Sheba Medical Center – Advanced, Personalized Transplant Care for Children

At Sheba Medical Center, we understand that a diagnosis of Non-Hodgkin Lymphoma (NHL) in a child, including Diffuse Large B-Cell Lymphoma (DLBCL), Follicular Lymphoma (FL), and Mantle Cell Lymphoma (MCL) is life-changing for the entire family.

When standard treatments are not enough, bone marrow transplantation (BMT) may offer a powerful and potentially curative option for children and adolescents.

Our pediatric transplant program combines world-class medical expertise, advanced technology, and a family-centered approach designed to support both the child and their loved ones throughout the entire journey.

When is a Bone Marrow Transplant Needed?

In pediatric NHL, a bone marrow transplant may be recommended when:

The lymphoma returns after initial treatment (relapsed disease)
The disease does not respond fully to standard therapies (refractory disease)
A more intensive treatment is needed to achieve long-term remission

The goal of BMT is to replace the affected bone marrow with healthy stem cells, allowing the child’s body to rebuild a new, healthy immune system capable of fighting the disease.

Types of Transplant

At Sheba, each child receives a personalized treatment plan based on their condition and medical needs:

Autologous Transplant (Child’s Own Cells)

Most commonly used in pediatric relapsed lymphoma, this approach uses the child’s own stem cells. They are collected, safely stored, and returned after high-dose therapy.

Allogeneic Transplant (Donor Cells)

Used in selected high-risk cases, this approach uses stem cells from a donor to build a new immune system that can also help fight lymphoma.

Finding the Right Donor

A suitable donor is a key part of successful treatment.

Whenever possible, a matched family donor (such as a sibling) is preferred. If this is not available, Sheba Medical Center works to identify the best possible alternative:

Matched unrelated donors from international registries
Haploidentical (half-matched) family donors
Cord blood units

Advanced laboratory testing ensures precise matching to improve safety and outcomes for children.

Specialized Pediatric Transplant Care

Children undergoing BMT at Sheba are treated in dedicated pediatric transplant units designed specifically for young patients. Care includes:

Child-friendly, highly protected environments
Advanced infection prevention systems
Individualized treatment protocols for pediatric lymphoma
Continuous monitoring by pediatric transplant specialists

Our approach is carefully adapted to the needs of growing children.

Clinical Expertise in Children

Sheba is one of the leading centers for pediatric bone marrow transplantation, offering:

Extensive experience in treating childhood NHL, including complex and high-risk cases
High success rates in autologous and selected allogeneic transplants
Long-term follow-up focused on healthy growth, development, and quality of life
Care That Supports the Whole Family

A pediatric bone marrow transplant is not only a medical procedure - it is a journey for the entire family.

At Sheba Medical Center, children are supported by a multidisciplinary team including pediatric oncologists, transplant specialists, nurses, psychologists, and social workers.

Families are guided through every stage, from diagnosis and preparation to transplant, recovery, and long-term follow-up.

Why Families Choose Sheba for Pediatric BMT
One of the leading pediatric transplant centers in the region
Expertise in pediatric DLBCL, FL, and MCL
Ability to identify optimal donors, even without a sibling match
Advanced transplant techniques tailored for children
Strong focus on safety, comfort, and emotional support
Dedicated international pediatric care coordination
A Message of Hope

At Sheba Medical Center, we combine advanced medical science with compassionate pediatric care. Our goal is to give every child the best possible chance for recovery, while supporting families with strength, clarity, and hope throughout the entire journey.

• Coordinatore medico personale
• Organizzazione dei viaggi medici — prenotazione di biglietti aerei e camere d'albergo a prezzi speciali per i partner
• Tutela degli interessi dei pazienti durante il viaggio medico