Sheba Pediatric CAR-T Program for Primary CNS Lymphoma

• Consulto con un ematologo
• Diagnosi completa dei linfomi
• Analisi estesa del sangue
• Esame del sangue per linfoma
• PET/CT nel linfoma
• Biopsia del linfonodo sentinella
• Diagnostica oncologica complessa
• Consulto con un oncoematologo
• Terapia con cellule CAR-T
• Test anti-HIV
• Test Anti-HBC
• Test Anti-HCVAb
• Esami del sangue
• Esame di biochimica del sangue
• Biopsia
• Radiografia del torace
• Emocromo completo (CBC)
• Consultazione con un oncologo
• Consultazione con un ematologo
• Consultazione con un immunologo
• Consultazione con un ematologo pediatrico
• Consultazione con un pediatra
• Emocromo completo con marcatori tumorali e proteinogramma
• Elettrocardiogramma (ECG)
• Ecocardiografia
• Consultazione con un cardiologo
• Risonanza magnetica della testa
• PET/TC
• Consultazione con un oncoematologo
• Servizi infermieristici 24 ore su 24
• 3 pasti al giorno dal nutrizionista

• 21 giorni in ospedale

• Trasferimento aeroporto-clinica-aeroporto

Sheba Pediatric CAR-T Program for Primary CNS Lymphoma

At Sheba Medical Center, children and young patients with primary central nervous system (CNS) lymphoma have access to one of the most advanced and specialized CAR-T therapy programs in the world. This rare and complex lymphoma, affecting the brain and spinal cord, requires highly precise and coordinated care, especially in relapsed or treatment-resistant cases.

A Personalized Treatment Designed for Each Patient

CAR-T therapy uses the patient’s own immune system to recognize and destroy cancer cells. For CNS lymphoma, this innovative approach offers a targeted option when conventional therapies are no longer sufficient.

At Sheba, the entire CAR-T process is performed on-site, ensuring speed, precision, and optimal cell quality:

Apheresis – collection of the patient’s T-cells
Cell Engineering – genetic modification at Sheba’s Advanced Biotherapy Center
Infusion – reintroduction of modified cells to target lymphoma cells

Because no steps are outsourced, treatment can begin quickly and is typically completed within ~10 days. CAR-T acts as a “living therapy,” continuing to work in the body and offering the potential for long-term disease control.

Expert Pediatric Leadership and Multidisciplinary Care

The program is led by Prof. Amos Toren, a globally recognized expert in pediatric hemato-oncology and cellular therapies, with decades of experience and over 1,500 bone marrow transplants performed.

Given the complexity of CNS lymphoma, care is delivered through a multidisciplinary team, including pediatric hemato-oncologists, neurologists, neurosurgeons, and radiology experts.

The program includes:

Specialized pediatric CAR-T units with 24/7 monitoring
Advanced neuro-imaging and precision diagnostics
A supportive, family-centered environment
Full international patient services, including travel and care coordination
Proven Expertise in Complex and High-Risk Cases

Sheba is a global leader in CAR-T therapy, with strong outcomes across hematologic cancers:

~90% remission in pediatric patients
~80% in young adults (up to 23 years)
~70% in adults

The team has extensive experience in treating rare and high-risk conditions, including CNS involvement, offering advanced options when other treatments are limited.

Comprehensive Evaluation and Ongoing Support

Each patient undergoes a full diagnostic work-up, including:
advanced brain and spinal imaging (MRI/CT), bone marrow evaluation, genetic and molecular testing, and cardiac and pulmonary assessment.

Care is provided in English, Russian, and Arabic, ensuring families feel supported and informed throughout the entire journey.

A Trusted Place for Advanced Pediatric Neuro-Oncology Care

By combining cutting-edge immunotherapy, neurological expertise, and compassionate care, Sheba provides one of the most advanced environments for treating primary CNS lymphoma with CAR-T—focused on achieving the best possible outcomes and quality of life for every patient.

• Coordinatore medico personale
• Organizzazione dei viaggi medici — prenotazione di biglietti aerei e camere d'albergo a prezzi speciali per i partner
• Tutela degli interessi dei pazienti durante il viaggio medico